We are currently witnessing a massive, unprecedented national shortage of estradiol patches in the United States. On the surface, you might think this is a reason to celebrate. After decades of suffering in silence, women are finally demanding hormone therapy, and doctors are finally writing prescriptions! But before we pop the champagne, we need to take a hard, critical look at the medical reality. The skyrocketing demand for estradiol patches highlights a catastrophic misunderstanding of female neuroendocrinology.